Thiazide like diuretics

Thiazide like diuretics

Thiazide like diuretics is drugs which are structurally similar to thiazides. They have a similar mechanism of action to that of thiazides. But thiazide like diuretics has a longer duration of action compared to thiazides.

Examples of Thiazide like diuretics

Chlorthalidone (Hythalton)

Thiazide like diuretics

Chlorthalidone is a phthalimidine derivative is absorbed slowly, and is not significantly metabolized. It remains preferentially bound to renal tissue for prolonged periods. Hence, its duration of action is up to 48 hours or more. It may be preferred in the treatment of hypertension. It is more liable to cause hypokalemia than the thiazides. It has been reported to be useful in the treatment of hypoparathyroidism where it corrects hypocalcemia without the danger of causing hypercalcemia which is inherent in vitamin D therapy of this condition.

Chlorexolone (Nefrolan)

Chlorexolone is a long action phthalimidine derivative is claimed to be more effective than chlorothiazide on weight basis.

Indapamide (Natrilix, Lorvas) and xipamide, (Xipamid) are used in the treatment of hypertension.

Clopamide (Brinaldix) is administered in a single daily dose of 20 to 60 mg. in the morning, on alternate days. It has longer duration of action (18-24 hr.). Blood urea levels are not affected during treatment.

Quinazolinones: Quinethazone and Metolazone belong to this group. These compounds have diuretic characteristics similar to those of benzothiadiazines.

As diuretics thiazide like diuretics offer hardly any advantage over thiazides and are almost similar to them.

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